Besides common nodes such as CYPs, APEX1, MAPT, which reflect the same function for cancer, cardiovascular and neurodegenerative as other flavonoid subclasses flavones contains other nodes such as ALDH1A1 in module 5, which reflect potential associations with cancer invasion (Yao et al., 2017; Li et al., 2018). This evidence concerns the gene ALDH1A1 and cancer.