While miR-33a/b and miR-122 directly controls cholesterol and lipid metabolism in concert with their host genes (reviewed in Moore et al., 2011; Fernandez-Hernando et al., 2013; Singh et al., 2017; Aryal et al., 2017), the SREBP transcription factors and represent the best studied miRNA in the context of metabolic liver diseases and NASH, miR-103 and miR-107 have recently emerged as new regulators of insulin and glucose homeostasis in the context of metabolic liver diseases (Joven et al., 2012; Chakraborty et al., 2014; Vienberg et al., 2017). The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.