For example, it has been reported that HDAC2, but not HDAC1 or HDAC3, is up-regulated in AD mouse models (Broide et al., 2007), but other reported differential changes in HDAC family levels, for example, the SAMP8 mouse model (Griñán-Ferré et al., 2016b). Here, HDAC3 is linked to Alzheimer disease.