WWOX and Alzheimer disease: An intra-N-terminal deletion isoform of TRAPPC6A, designated TRAPPC6AΔ or TPC6AΔ, tends to spontaneously form aggregates or plaques in the extracellular matrix of the hippocampi of postmortem middle-aged normal humans and older AD patients (Figure 4C) and 3-week-old Wwox gene knockout mice (Figure 4D) (Chang and Chang, 2015; Chang et al., 2015).