Deficiency of WWOX/Wwox gene due to point mutations or homozygous nonsense mutation may result in childhood onset autosomal recessive cerebellar ataxia and epilepsy, growth retardation, microcephaly with seizure, retinal degeneration, and early death at 16 months of age (Valduga et al., 2015; Alkhateeb et al., 2016; Elsaadany et al., 2016). Here, WWOX is linked to microcephaly.