GSK3B and Alzheimer disease: GSK-3β is known to hyperphosphorylate Tau which leads to restriction of neurite outgrowth, and prevention of neuronal differentiation resulting in formation of neurofibrillary tangles (NFTs) and senile plaques (SPs) in AD (Augustinack et al., 2002; Avila et al., 2010; Chang et al., 2014; Llorens-Martin et al., 2014; Sze et al., 2004).