Deposits of calcium oxalate in bone and other tissues is known as oxalosis and it is a secondary to the occurrence of primary hyperoxaluria (PH) due to an autosomal recessive hereditary disorder of the metabolism of glyoxylate, most frequently caused by a enzyme deficit of alanine-glyoxylate aminotransferase (PH type I) located in the hepatic peroxisomes which causes excessive oxalate production with involvement of the kidney, the excretory organ [63]. The gene discussed is AGXT; the disease is primary hyperoxaluria.