Indeed, treatment with atRA alone or in combination with calcitriol (an active vitamin D metabolite) in murine autoimmune encephalomyelitis (EAE), which is an experimental model of MS, increased the expression of the Foxp3 and TGF-β genes in splenocytes while reducing RORγt gene expression [139]. The gene discussed is TGFB1; the disease is myeloid sarcoma.