ONCOS-102 is an adenovirus with an engineered capsid for enhanced cancer cell transduction and a deletion in the E1A gene, which also promotes proliferation, that binds the tumor suppressor, the retinoblastoma protein (Rb), rendering the viral replication to cells that lack Rb, also commonly observed in soft tissue sarcoma [68, 69]. The gene discussed is RB1; the disease is soft tissue sarcoma.