Levels of NaV1.6 protein expression were similar in low-grade cervical intraepithelial neoplasia (CIN1) and non-cancerous cervix (NCC) (Fig. 2A, top two rows), but they were substantially lower compared to high-grade cervical intraepithelial neoplasia (CIN3) and CeCa (Fig. 2A, bottom two rows), suggesting that the up-regulation of NaV1.6 protein occurs when the human cervical cells have been transformed and the tissue shows histological invasive characteristics. Here, SCN8A is linked to cervical intraepithelial neoplasia.