This observation could be a partial explanation for the widely distributed immunoreactivity signal of NaV1.6 channel in cervical cancer cells and tissues compared with the localized plasma membrane signal in non-cancerous slice tissues (Figs 2 and 3), as the Δ18 variant of NaV1.6 channels has been localized only in intracellular compartments23. The gene discussed is SCN8A; the disease is cervical carcinoma.