The differences included the psychosis-related phenotypes: reductions in METH-induced hyperactivity due to reduced dopamine release were observed in the Relnrl-Orl/+ mice, whereas delusions and hallucinations, which are assumed to result from a hyper-responsive dopamine system, were observed in the patient with the exonic deletion of RELN. Although the precise reason for this discrepancy is unclear, it is possible that functional effects of the two mutations may not be exactly the same. Here, RELN is linked to psychotic disorder.