DJ-1 has been demonstrated to be overexpressed in many types of tumor, including uveal melanoma, non-small cell lung carcinoma (NSCLC), hepatocellular carcinoma, pancreatic ductal adenocarcinoma (PDAC), ovarian carcinoma, breast cancer, and esophageal squamous cell carcinoma (ESCC)3. This evidence concerns the gene PARK7 and esophageal squamous cell carcinoma.