Accumulating evidence has shown that DJ-1 can promote cancer cell survival, proliferation, and metastasis by multiple mechanisms, such as regulating redox balance, activating Akt/mTOR, MEK/ERK, NF-κB, and HIFα signaling pathways, or repressing p53, JNK, and ASK1 signaling pathways2. This evidence concerns the gene PARK7 and cancer.