RIPK3 and hyperinsulinemic hypoglycemia, familial, 4: The serum concentrations of creatinine and BUN were significantly lower in Ripk3 deficiency (Ripk3−/-), Mlkl deficiency (Mlkl−/−) and Ripk3/Mlkl double deficiency (Ripk3−/−Mlkl−/−) mice than all WT mice from day 2 to day 14 after IRI (Fig. 1c, d).