In addition, the knockdown of ZEB1 expression using two different specific siRNA (Si-ZEB1 (1) and Si-ZEB1 (2), Fig. 5b, c) mimics α6-integrin downregulation, by increasing radiosensitivity of neurospheres derived from human GBM biopsy specimens (Fig. 5d, e). This evidence concerns the gene ZEB1 and glioblastoma.