In agreement, in H400 cancer cells that can be sensitized to Poly(I:C)-triggered apoptosis when the c-FLIP, but not cIAPs, brake only is released (Fig. 2), paclitaxel also reduced the expression of c-FLIP (Supplemental Fig. 3e), and sensitized these cells to TLR3-mediated death (Supplemental Fig. 3f). The gene discussed is TLR3; the disease is cancer.