RASAL2, a unique RAS GTPase-activating protein (RAS-GAP), has been reported as a tumor-suppressor gene, which inhibits tumor progression in different types of cancer, such as luminal B breast cancer, ovarian cancer, lung cancer, nasopharyngeal carcinoma, and colorectal cancer8–12. The gene discussed is RASA2; the disease is nasopharyngeal carcinoma.