For example, Rab2A, Rab3D, Rab8, Rab11, Rab21, Rab22A, Rab23, Rab25, Rab27B, and Rab35 promote tumor cell migration, invasion and metastasis by disrupting the homeostasis of intracellular signal transduction and vesicles trafficking4–13. Here, RAB27B is linked to neoplasm.