Furthermore, the expression of stemness genes ABCG2, Nanog, Notch1 and Oct4 as well as Wnt-related genes CCND1, c-Jun, VEGF, and c-myc in tumor xenografts was down-regulated in shRab37 + rSFRP1 group (Fig. 4f, symbols pink vs. red). The gene discussed is POU5F1; the disease is neoplasm.