Analysis of the transposon insertion sites in these tumors resulted in the identification of two RasGAP genes (Nf1 and Rasa1) as two of the genes most frequently mutated in these mammary tumors, and we established that loss of these genes is a common event in human triple negative breast cancer, thus confirming the implication of the Ras pathway in breast cancer9. The gene discussed is RASA1; the disease is triple-negative breast carcinoma.