Above results suggested that CAFs-derived HGF increased IL-6R expression in MET-unamplified GC cells through HGF/c-Met/ERK1/2 signaling pathway, and that CAFs-derived IL-6 increased c-Met expression in MET-unamplified GC cells through IL-6/IL-6R/JAK2/STAT3 signaling pathway. This evidence concerns the gene HGF and gastric cancer.