RASAL1 and renal fibrosis: Most importantly, renal fibrosis, accumulation of fibroblasts and type I collagen were significantly attenuated in dCas9/dHFCas9-TET3CD-Rasal1-sgRNA4 treated mice, but not in mice administered with the dCas9/dHFCas9-TET3CD-LacZ-sgRNA control vectors (Fig. 5g–j).