Inhibition of NUAK2 with WZ4003 blocked nuclear accumulation of YAP/TAZ in SW480, an APC mutant colorectal cancer cell line, as well as in TCCSUP, T24, and RT112, three bladder cancer-derived lines (Fig. 6e, f and Supplementary Fig. 7a). This evidence concerns the gene NUAK2 and urinary bladder cancer.