Since MHYs induced neither Src phosphorylation nor apoptosis in EGFR null colon cancer SW620 cells and inhibition of Src activity by a chemical inhibitor or siRNA approach completely blocked MHY-mediated cell death, the cytotoxic effects of MHYs require not only EGFR inhibition but also Src activation. The gene discussed is SRC; the disease is malignant colon neoplasm.