To further evaluate MYC-PNUTS interaction beyond the MCF10A cell line, we also evaluated A549 (lung adenocarcinoma), Daudi (lymphoma) (Supplementary Fig 3a images (left) and histogram (right)), OCI-AML3 (AML3) (leukemia), and H520 (squamous cell lung cancer) (Supplementary Fig. 3b images (left) and histogram (right)) cells and observed MYC-PNUTS interaction. Here, RUNX2 is linked to leukemia.