SPON2 and benign prostatic hyperplasia: One of these proteins, SPON2, was also highlighted in a study by Qian et al. [76], investigating conditioned media from BPH-1 (BPH epithelial cell line), LNCaP, and C4-2 (androgen independent derivative of LNCaP) cell lines using 2DE in combination with LC-MS/MS [76].