Based on the availability of antibodies, nine proteins were further evaluated using WB on 173 urine samples (n = 90 PC, n = 83 BPH), and significant increase of β-2-microglobulin (β2M), Pepsin A-3 (PGA3), and Mucin-3A (MUC3A) 25kDa were verified. The gene discussed is PGA3; the disease is pachyonychia congenita.