Differential expression of three of these, namely cartilage Oligomeric matrix protein, Periostin, and Membrane primary amine oxidase was validated using ELISA in an independent set of tissue samples (12 normal prostate tissue from transplant donors, 27 nonaggressive prostate tumor, 20 aggressive prostate tumors, and 10 prostate metastases) [86]. This evidence concerns the gene POSTN and prostate neoplasm.