PROS1 and benign prostatic hyperplasia: ROC analysis for individual markers showed an AUC of 0.68 for PSA (p = 0.006), 0.60 for SAA1 (p = 0.117), and 0.61 for TSR1 (p = 0.081) in discriminating nonmalignant (BPH + healthy controls) from malignant samples.