Conversely, the M2 type involved in parasite containment and tissue remodelling, were characterized by the IL4 induced gene expression of anti-inflammatory proteins including Ym1, arginase 1 (ARG1) and type 2 cytokines such as IL10. Thereby, this M1 and M2 terminology was used to generally depict the proinflammatory state of largely recruited ATMs in obesity versus the predominant anti-inflammatory state of resident ATMs in leanness [92]. Here, ARG1 is linked to obesity due to melanocortin 4 receptor deficiency.