Many GPCRs that indicate poor prognosis of prostate cancer signal via the Gα12/Gα13—RhoA axis via PKC for NF-κB activation [140,141,142], but GPCRs also induce several other transcriptional regulators relevant for cancer, like AP-1, MRTF-A and YAP [140]. This evidence concerns the gene PRRT2 and Familial prostate cancer.