GLI1 and breast cancer: Table 3 shows an overview of several studies examining combined effects of downstream Hedgehog inhibition with inhibition of other pathways, and in the majority of cases the effect is synergistic. It is interesting to note that in breast cancer cells, combined treatment of tamoxifen with SMO inhibitor exerts a different response that combined treatment with GANT61. In the case of cyclopamine, the cells show short-term survival while this is not the case when using GLI inhibitors [258,259].