HSP90B1 and Parkinson disease: Recently, a vaccine composed of combination of α-synuclein (α-Syn) and Grp94 chaperone could provide a marked long-lasting immune profile in the peripheral system, which has an influence on the CNS by inhibiting chronic microglial activation in chronic mouse 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP)-model of Parkinson’s disease (PD) [240].