rhENPP1 ERT could also be a promising therapy for other diseases caused by loss-of-function mutations in ENPP1 or low plasma PPi levels, or characterized by ectopic vascular calcification, such as pseudoxanthoma elasticum, autosomal-recessive hypophosphatemic rickets and chronic kidney disease. The gene discussed is ENPP1; the disease is pseudoxanthoma elasticum (inherited or acquired).