IFNL3 and lupus nephritis: Paradoxically, our study revealed that the most common IFNL3/4 SNP haplotype rs8099917T/rs12979860C/rs4803217C (high IFN-λ3 producer) was significantly associated with the risk for lupus nephritis, while the minor haplotype rs8099917G/rs12979860T/rs4803217A (low IFN-λ3 producer) had a protective role against lupus nephritis.