As shown in Table 2, all minor IFNL3/4 SNP alleles were significantly associated with SLE susceptibility in patients negative for nephritis compared to healthy controls adjusted for sex and age (rs8099917G, PFDR = 0.00177, OR 1.68, 95% CI 1.24–2.28; rs12979860T, PFDR = 0.00299, OR 1.58, 95% CI 1.18–2.32; rs4803217A, PFDR = 0.00176, OR 1.65, 95% CI 1.22–2.23; and ss469415590ΔG, PFDR = 0.00176, OR 1.70, 95% CI 1.26–2.29). The gene discussed is IFNL3; the disease is nephritis.