Previous studies have demonstrated that downregulating HMGB1 in cancer cells such as gastric cancer [19], bladder cancer [20], and non-small cell lung cancer [21] through RNA interference (RNAi) or micro-RNA overexpression can inhibit cell proliferation and induce cell cycle arrest or apoptosis to increase the sensitivity of tumor cells to chemotherapy [5]. This evidence concerns the gene HMGB1 and gastric cancer.