In addition, the active RA group had the highest ratios of Tfh cells to Tfr cells (36.5 ± 5.6%), followed by the inactive RA group (23.6 ± 3.2%) and the control group (10.2 ± 0.8%) (P < 0.05, Fig. 1c). Here, TFRC is linked to rheumatoid arthritis.