Interestingly, in addition to ALP and RUNX2 mRNA, other osteogenesis-associated genes such as catenin beta 1 (CTNNB1) and cadherin 11 (CDH11) were also significantly upregulated in pre-miR-218 transfected RA-FLS compared to the scrambled control from 72 h after transfection (Fig. 3c). This evidence concerns the gene RUNX2 and rheumatoid arthritis.