AKT1 and breast carcinoma: In other studies of the relationship between PD-1/PD-L1 and EMT, Alsuliman et al. [103] showed that PD-L1 induced EMT in tumor cell lines via the PI3K/AKT and ERK/MEK pathways in breast cancer and that the involvement of the PI3K/AKT pathway was more important in this process.