In addition, a regulatory role of the hsa_circ_00006528-miR-7–5p-Raf1 axis in ADM-resistant breast cancer was identified, suggesting that hsa_circ_00006528 expression is significantly associated with ADM-resistant breast cancers and demonstrate the potential function of hsa_circ_00006528 in overcoming drug resistance. Here, RAF1 is linked to breast cancer.