HSP90B1 and neoplasm: For example, endoplasmin and triosephosphate isomerase were found downregulated in our metastatic lymph node samples, and upregulated in tumor samples analyzed by Nomura H et al. [87] and Polachini GM et al. [88], which may be explained by the effect of the lymph node immune environment in modulating tumor growth or in metabolic reprogramming of the metastatic cell considering the blood flow, oxygen and nutrient supplies in the secondary site.