In fact, the genes encoding some of these proteins showed the highest scores for gene-to-HNSCC association determined by HNdb hypergeometric test, namely FABP5, S100A7, ANXA1, LGALS1, PARK7, GSTP1, with scores ranging from 1.88 to 83. The gene discussed is ANXA1; the disease is head and neck squamous cell carcinoma.