A separate report also utilized subcutaneous tumor xenograft model to reveal cellular retinoic acid binding protein 2 (CRABP2) as a tumor suppressor by showing slower growth rate of subcutaneous tumors derived from EC109 ESCC cells overexpressing CRABP2 when compared to the control experimental group [12]. The gene discussed is CRABP2; the disease is esophageal squamous cell carcinoma.