MAP3K3 and neoplasm: Highly upregulated gene, immediate early gene (Egr1) (Table 1), encodes a nuclear, zinc finger protein and its transcription directly regulates multiple tumor suppressors such as TGFbeta, PTEN, p53, and fibronectin, as well as the Sgk1 gene that phosphorylates BRAF and MAP3K3 and inhibit their activities [30].