ID2 and melanoma: Moreover, treatment with gnidilatidin has shown that at the signal transduction level, gnidilatidin increased the expression of MITF and the direct regulator of tumor suppressors, Egr1, accompanied by a downregulation of tumor cell migration and invasion-associated gene Id2, providing further proof on the potential of daphnane diterpenes for use as therapeutics against melanoma metastasis, either alone or in combination with other daphnane diterpenes or existing anti-cancer drugs.