SERPINA3 and paracoccidioidomycosis: The analysis of patient serum samples drawn at admission revealed the presence of the alpha-1-antichymotrypsin protein (SERPINA 3) in patients with active PCM, with no quantitative difference among those caused by P. brasiliensis, either with or without subsequent relapse, and those by P. lutzii. Since alpha-1-antichymotrypsin (SERPINA 3), a protease inhibitor protein that acts on lipid metabolism, is present during inflammatory processes, including those of infectious etiology, these findings corroborate those of the literature [31].