APLN and obesity due to melanocortin 4 receptor deficiency: In the present study, metabolic and weight reducing effects of chronic once daily administration of (Lys8GluPAL)apelin-13 amide and pGlu(Lys8GluPAL)apelin-13 amide were directly compared to the GLP-1 mimetic, liraglutide using a high-fat fed mouse model diet-induced obesity-diabetes (DIO).