Importantly, transcriptomics analysis of the screened 941 cancer cell lines revealed that high AXL and TYRO3 mRNA levels predict both resistance to necroptosis and low RIPK3 mRNA levels (Figs 2F and 3A–3D, S3 Table), but not those of RIPK1, MLKL, or any other pro-necroptotic genes (S4A Fig). Here, RIPK3 is linked to cancer.