Importantly, while ex vivo–cultured tumor xenograft cells were sensitive to TNFα+SM-164+zVAD.fmk (TSZ)-induced necroptosis at passage zero, they were fully resistant after the third in vivo serial xenograft, and because of the resistance to cell death, this treatment of TSZ did not induce cell death, but rather induced cell growth resulting in an approximately 140% survival rate (Fig 1F and S1B Fig). The gene discussed is TNF; the disease is neoplasm.