RIPK3 and cancer: Consistent with the notion that oncogenic BRAF and AXL kinases promote the loss of RIPK3 expression in cancer cells, 14 out of 20 cell lines that harbor mutations promoting BRAF activation or high levels of AXL (or TYRO3) experienced loss of RIPK3 expression during in vivo passaging, while 13 out of 16 cell lines that lack such mutations did not experience that effect (S6 Table).