Clustering analysis (Fig 3D) revealed that majority of the analyzed cancer cell lines that are resistant to necroptosis (high IC50, cluster 1, about 83%) are either AXLhigh (cluster 2, about 28%) or TYRO3high (cluster 3, about 14%), while the majority of those that are sensitive to necroptosis (low IC50) are RIPK3high and have low/medium AXL/TYRO3 levels (cluster 4, about 19%). The gene discussed is AXL; the disease is cancer.