MLKL and neoplasm: The presence of MLKL phospho-Ser358 marker in the tumor xenografts (Fig 1D) may also indicate that other roles of MLKL unrelated to cell death are at play during tumorigenesis, because phosphorylation of MLKL at this residue has been shown to be not sufficient to commit to necrotic cell death, as demonstrated in a recent study that links the ESCRT-III complex downstream of MLKL [59].