In addition, high levels of CLCC1 retinal expression and especially in the photoreceptors and RPE, are consistent with CLCC1 mutation causing a retinal degeneration as is the finding that knocking out CLC3, another endosomal chloride channel, results in degeneration of the retina and hippocampus [31]. The gene discussed is CLCN3; the disease is retinal degeneration.