RREB1 and intervertebral disk degenerative disorder: A growing number of studies indicated that lncRNAs were correlated with the development of several diseases.23, 37, 38, 39 The role of lncRNAs in the development of IDD has also been explored.29, 31, 40 For example, Wang et al41 found that lncRNA linc‐ADAMTS5 cooperates with RREB1 to suppress ADAMTS5 expression, then affecting ECM degeneration of the IVD.