For example, among patients with rheumatoid arthritis, investigators found that TNF‐alpha was suppressed after two months of CoQ10 supplementation as compared to placebo.30 In another trial of multiple sclerosis patients treated with CoQ10, subjects who received CoQ10 therapy had both lower levels of TNF‐alpha and IL‐6 compared to placebo after 12 weeks.31 Given the potential anti‐oxidative and anti‐inflammatory capacity of CoQ10, we expected our finding of low levels of CoQ10 to be associated with an increase in inflammatory markers. This evidence concerns the gene TNF and rheumatoid arthritis.