In fact, several studies have demonstrated a restoration of the T cell mediated response to either influenza infection or vaccination with the addition of IL‐2 in vitro in older subjects in whom this type of immunity has waned.32, 33 While our findings of an inverse relationship between CoQ10 and TNF‐alpha and IL‐2 are associative, a previous laboratory investigation of CoQ10 in peripheral blood mononuclear cells (PBMCs) suggests a potential causal relationship; Bessler et al. This evidence concerns the gene TNF and influenza.