In this study, we explored the SNP interactions between PGC and its neighbor lncRNAs on the risk of AG and GC, the modifying effects of environmental factors such as smoking, drinking, and Helicobacter pylori (H. pylori) infection, and the influence of SNP interactions on the expression of PGC protein and related lncRNAs. Here, PGC is linked to Helicobacter pylori infectious disease.