PGC and gastric cancer: It serves as a proteinase involved in the digestion of protein in stomach, and its levels significantly decrease in AG and dysplasia implicating poorly differentiated cells and are more susceptible to GC.10 Furthermore, the serum PGII level has been proven to be promising biomarkers for diagnosis of GC and AG in recent years.36, 37 Therefore, PGC protein has close relationship with malignancy of gastric mucosa and could well recognize the risk of malignant gastric lesions.