MAPT and synucleinopathy: We determined in previous in situ characterizations of these two candidate intrabodies that although NbSyn87*PEST clears α-syn more effectively than VH14*PEST, VH14*PEST modifies cellular stress associated with multi-factorial proteostasis to a greater extent, particularly in the case of α-syn promotion of mutant huntingtin proteinopathy.22 This aspect of intervention is integral for synucleinopathies that are commonly associated with concomitant pathology of additional proteins vulnerable to disordering or misfolding such as tau, amyloid-β, and mutant huntingtin.