In conclusion, this study showed that miR-122 expression is decreased in HNF1A-DM patients compared to T2DM patients and healthy subjects, which might partially explain the abnormal lipid metabolism and an increased risk for liver neoplasms in HNF1A-DM patients and help us understand the nature of HNF1A-DM. This evidence concerns the gene HNF1A and Neoplasm of the liver.