DSG1 and acquired polycythemia vera: Moreover, assessment of Dsg3 and 1 titers in PV patients have demonstrated the existence of cutaneous only patients (with no history of mucosal lesions) with no detectable anti-Dsg1, mucosal only patients with no detectable anti-Dsg3, as well patients that lack detectable titers of anti-Dsg3 or 1 autoAbs (28–43), all of which cannot be explained by the desmoglein compensation hypothesis (Table 1).