When performing the promoter region analysis of genes up-regulated in ER- breast tumors showing high levels of NOS2 expression, Switzer et al. observed that the common denominator of the promoters of these genes was the presence of the Ets-binding sequence, pointing at the role of this transcription factor in the NOS2 (and thus NO)-dependent oncogenic signaling (72). The gene discussed is NOS2; the disease is breast neoplasm.