AKT1 and cancer: Intriguingly, PTEN inactivation upon S-nitrosylation was originally identified in the context of neurodegenerative diseases (56), whereas Gupta and coworkers, for the first time, demonstrated the role of this redox-dependent modification in supporting proliferation and survival of cancer cells through the activation of PI3K/Akt signaling and the subsequent stimulation of mTOR activity (55).