Alcoceba et al. found diffuse large B cell lymphoma (DLBCL) patients had a higher phenotypic frequency of HLA-DRB1*01 and a lower frequency of HLA-C*03 compared with healthy individuals [2]. Our previous studies showed that several HLA alleles were associated with susceptibility in leukemia [3, 4]. Here, HLA-C is linked to diffuse large B-cell lymphoma.