Besides, these immune-relevant UAGs and some of their interacted DAGs are also highly enriched in oncogenic signaling pathways, including Ras, nuclear factor kappa-light-chain-enhancer of activated B cells(NF-kappa B), phosphatidylinositol 3-kinase(PI3K)/AKT, Notch and P53 signaling pathways, which implies that senescent cells resemble cancer cells. Here, TP53 is linked to cancer.