IFN-γ orchestrates the infiltration of Th1 and Tc1 cells in the COPD lungs through the upregulation of the chemokine receptor, CXC-chemokine receptor (CXCR) 3, on these cells and the release of the CXCR3-activating chemokines [51]. The gene discussed is CXCR3; the disease is chronic obstructive pulmonary disease.